Adverse drug reactions in nephrology ward inpatients of a tertiary care hospital.
Indian J Med Sci
;
2007 Oct; 61(10): 562-9
Article
in English
| IMSEAR
| ID: sea-66869
ABSTRACT
BACKGROUND:
Adverse drug reactions (ADRs) are important causes of hospital admissions and inpatient complications. Renal dysfunction has a role in occurrence of ADRs.AIMS:
(1) To study the characteristics of ADRs among inpatients in Nephrology ward of a tertiary care hospital and (2) to compare these characteristics between patients with renal dysfunction and patients with normal renal function in same population of patients with ADRs. MATERIALS ANDMETHODS:
A retrospective study of inpatients with ADRs (July 2005-June 2006) in Nephrology ward of a tertiary care hospital. STATISTICALANALYSIS:
ADR characteristics were analyzed using descriptive statistics. Comparisons were made between normal renal function group and renal dysfunction group by t-test and Chi-square test.RESULTS:
Of 1,464 case records, 244 (17%) patients were included. Two hundred sixty-seven drugs contributed to 294 ADRs. Serious ADRs accounted for 12% of the total ADRs. Renal/ electrolyte system (44%) was the most common organ system involved. Major clinical spectrum of ADRs included acute renal failure (22%), hypo/ hyperglycemia (13%), hyper/ hypokalemia (13%), bone marrow suppression (5%) and hepatic injuries (4%). Prednisolone (12%) was the most commonly implicated drug. Mean time to revert was 13+/-7.2 days. Three patients died. On comparing patients with normal renal function (n=80) with those suffering from renal dysfunction (n=164), polypharmacy, serious ADRs, multiple ADRs, longer time to recover, longer period of hospitalization were found to be more frequent among the renal dysfunction group (PCONCLUSIONS:
High incidence of ADRs, especially serious and life-threatening ADRs, was noticed. A wide spectrum of ADRs was observed. Renal dysfunction showed a significant impact on various characteristics of ADRs.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Drug Prescriptions
/
Aged
/
Female
/
Humans
/
Male
/
Pharmaceutical Preparations
/
Case-Control Studies
/
Retrospective Studies
/
Risk Factors
/
Adolescent
Type of study:
Etiology study
/
Observational study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Med Sci
Year:
2007
Type:
Article
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