Atherosclerosis in diabetes mellitus: role of inflammation.
Indian J Med Sci
;
2007 May; 61(5): 292-306
Article
in English
| IMSEAR
| ID: sea-66906
ABSTRACT
Inflammation plays a central role in the pathophysiology of atherosclerosis, starting from initiation, through progression and ultimately the thrombotic complications of atherosclerosis. Diabetes mellitus is a major risk factor for atherosclerosis. Hyperglycemia-induced endothelial dysfunctions, along with hypercoagulable potential of diabetes mellitus, accelerate the process of atherothrombotic complications. Therefore, clinically feasible markers to monitor subtle systemic inflammatory burden and specific add-on therapy for the same constitute need of the present day. The understanding of the concept of inflammation in diabetes-accelerated atherosclerosis can be used practically to predict future cardiovascular risk by evaluating inflammatory biomarkers and to design clinical trials making inflammation as a therapeutic target.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Endothelium, Vascular
/
Biomarkers
/
Risk Factors
/
Oxidative Stress
/
Disease Progression
/
Diabetes Complications
/
Atherosclerosis
/
Inflammation
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Language:
English
Journal:
Indian J Med Sci
Year:
2007
Type:
Article
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