Combination of thrombophilia markers in acute myocardial infarction of the young.
Indian J Med Sci
;
2004 Sep; 58(9): 381-8
Article
in English
| IMSEAR
| ID: sea-67037
ABSTRACT
BACKGROUND:
The pathogenesis of arterial thrombotic disease involves multiple genetic and environmental factors related to atherosclerosis and thrombosis. But, there have been very few studies in India which have investigated some of the thrombophilia markers.AIM:
To look for combined thrombophilia in MI patients. SETTINGS ANDDESIGN:
One hundred twenty patients of myocardial infarction (age below 40 yrs.) were recruited 8-10 weeks after stabilization. Hundred age and sex-matched healthy controls were also recruited in the present study. METHODS ANDMATERIAL:
Following thrombophilia markers were screened in these patients--plasma fibrinogen, protein C, protein S, antithrombin III, factor V Leiden, PT G20210A polymorphism, MTHFR C677T, homocysteine, fibrinogen b448 Arg/Lys polymorphism and CBS T833C mutation. STATISTICALANALYSIS:
Statistical analysis was done using Statistical Package for Social Sciences (SPSS) version 10.0, SPSS Inc., Chicago, USA. RESULTS ANDCONCLUSION:
Elevated fibrinogen levels, homocysteine (p< 0.001 and homocysteine with odds ratio 6.26) and factor V Leiden (p=0.038) were independently associated with MI in our patients. A total of 37 patients (42.5%) had the presence of more than one thrombophilia markers in combination. Out of these, 10 had the presence of three markers in combination and 1 had five thrombophilia markers in combination. Only 2 controls had prothrombotic markers in combination. Combined prothrombotic risk factors were significant in cases in comparison to controls (p< 0.001). Further larger studies on a nationwide basis recruiting a large number of young MI patients should be done to substantiate these findings.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Humans
/
Male
/
Factor V
/
Fibrinogen
/
Protein C
/
Echocardiography
/
Biomarkers
/
Antithrombin III
/
Risk Factors
Type of study:
Etiology study
/
Risk factors
Language:
English
Journal:
Indian J Med Sci
Year:
2004
Type:
Article
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