Association of CYP1A1*2 polymorphisms with breast cancer risk: a case control study.
Indian J Med Sci
;
2009 Jan; 63(1): 13-20
Article
in English
| IMSEAR
| ID: sea-67183
ABSTRACT
BACKGROUND:
The Cytochrome P-4501A1 (CYP1A1) gene, located on chromosome 15q, is involved in the metabolism of carcinogens mainly polycyclic aromatic hydrocarbons as well as estrogen. It is considered as candidate gene for low-penetrance breast cancer susceptibility. Hence the present study aims to discuss the role of CYP1A1 polymorphisms in breast cancer. MATERIALS ANDMETHODS:
A total of 250 breast cancer patients and the same number of healthy age-matched controls were analyzed for the polymorphism of CYP1A1*2 by polymerase chain reaction-restriction fragment length polymorphism.RESULTS:
In the present study, association of CYP1A1*2 (Ile 462Val) polymorphism with breast cancer was studied. Only one breast cancer patient was observed to be homozygous for Val allele but none among controls. The frequency of heterozygous Ile/Val genotype was found to be increased significantly in breast cancer patients (68.1%) as compared to controls (51.0%). Higher frequency of heterozygotes for Val allele was observed among premenopausal breast cancer patients and patients with high BMI, positive for HER2/neu status and advanced stage of the disease in comparison to the corresponding groups. No significant association of CYP1A1*2 polymorphism was observed with occupation, estrogen receptor and progesterone receptor status of breast cancer patients.CONCLUSIONS:
In conclusion, our results suggest a significant correlation between CYP1A1*2 expression and the occurrence of breast cancer.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Polymorphism, Genetic
/
Breast Neoplasms
/
Female
/
Humans
/
Receptors, Progesterone
/
Receptors, Estrogen
/
Case-Control Studies
/
Risk Assessment
/
Cytochrome P-450 CYP1A2
/
Genetic Predisposition to Disease
Type of study:
Etiology study
/
Observational study
/
Risk factors
Language:
English
Journal:
Indian J Med Sci
Year:
2009
Type:
Article
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