Hypolipidemic effects of synthetic gugulsterones in normal rats and assessment of its long-term toxicity at cellular levels in various organs.
Indian J Med Sci
;
1996 Mar; 50(3): 63-7
Article
in English
| IMSEAR
| ID: sea-67237
ABSTRACT
Synthetic gugulsterones when administered to rats for a period of 3 weeks in dose of 5.0 mg/kg body weight/day caused a reduction in levels of total cholesterol by 30%, LDL-chol. by 40%, Tg by 40%. VLDL-chol. by 40% and HDL-chol. by 35%. The drug when administered to rats for a period of 16 weeks with increasing dose upto 1150 mg/kg body weight/day, reduced VLDL-chol. and Tg. by 55% and 50% respectively (P < 0.001) and LDL-chol by 33% (P < 0.05), whereas HDL-chol. was increased by 25% (P < 0.001). Histopathological studies on liver, spleen, intestine, lung, kidney, stomach and adrenal gland revealed drug related changes in a few animals upon exposure to high dose of the drug.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Plant Extracts
/
Rats, Wistar
/
Drug Evaluation, Preclinical
/
Lipids
/
Animals
/
Hypolipidemic Agents
Language:
English
Journal:
Indian J Med Sci
Year:
1996
Type:
Article
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