Opioid receptor mediated anticonvulsant effect of pentazocine.
Indian J Med Sci
;
1998 Jan; 52(1): 1-7
Article
in English
| IMSEAR
| ID: sea-67367
ABSTRACT
Intraperitoneal (i.p.) administration of (+/-) pentazocine (10, 30 & 50 mg/kg), a Sigma opioid agonist, resulted in a dose dependent anticonvulsant action against maximal electroshock seizures in mice. This anticonvulsant effect of pentazocine was not antagonized by both the doses of naloxone (1 and 10 mg/kg) suggesting thereby that its anticonvulsant action is probably mediated by Sigma opiate binding sites. Its anticonvulsant effect was potentiated by both the anticonvulsant drugs viz. diazepam and diphenylhydantoin. Morphine, mu opioid agonist, on the other hand, failed to protect the animals against maximal electroshock seizures when it was given in doses of 10-40 mg/kg body wt.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pentazocine
/
Seizures
/
Female
/
Male
/
Treatment Outcome
/
Diazepam
/
Disease Models, Animal
/
Dose-Response Relationship, Drug
/
Drug Interactions
/
Analgesics, Opioid
Language:
English
Journal:
Indian J Med Sci
Year:
1998
Type:
Article
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