Effect of cimetidine on weight gain in rats.
Indian J Med Sci
;
1995 Nov; 49(11): 257-60
Article
in English
| IMSEAR
| ID: sea-67909
ABSTRACT
Effect on food intake and body weight was studied in rats after oral administration of cimetidine. Rats in experimental (E) group exhibited less increase in food intake (20%) compared to control (C) rats (43.8%). Mean body weight showed first reduction (-9.56%) and then very small increment in experimental animals compared to gradual gain in body weight in control animals. At the end of 6 weeks, total gain in body weight was 22.5 gm in rats of E group against 53.8 gm in rats of C group. Food efficiency ratio (FER) showed much reduction (1.13) in E group against 2.07 in C group. These results demonstrate that cimetidine (H2-receptor blocker) may have ability to reduce food intake and body weight in rats.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Female
/
Male
/
Weight Gain
/
Cimetidine
/
Rats, Wistar
/
Eating
/
Histamine H2 Antagonists
/
Animals
Language:
English
Journal:
Indian J Med Sci
Year:
1995
Type:
Article
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