Comparative evaluation of efficacy and safety profile of three anti-tuberculous regimens in Mangalore.
Indian J Med Sci
;
2002 Jul; 56(7): 315-20
Article
in English
| IMSEAR
| ID: sea-68058
ABSTRACT
The aim of our study was to evaluate and compare the therapeutic efficacy & safety profile of three different antituberculous regimens for pulmonary tuberculosis. The study sample size included 90 newly diagnosed, sputum positive patients of pulmonary. tuberculosis. 30 each from different groups. The parameters studied were, therapeutic efficacy included weight gain, cough, sputum examination and safety profile nausea, vomiting, anorexia, gastritis, hepatitis, jaundice diarrhoea, rashes, dizziness, tingling & numbness, flu like symptoms & joint aches. Group-I showed statistically significant weight gain when compared to Group-II. Improvement in cough and conversion to smear negative were seen in 100% of patients in Group-I, 83.3% of patients in Group-II and 93.3% of patients in Group-III. Therapeutic efficacy was highest with Group I regimen, followed by Group III and Group II which was least efficacious. Group II also registered; the maximum cost and highest incidence of adverse effects.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pyrazinamide
/
Rifampin
/
Tuberculosis, Pulmonary
/
Female
/
Humans
/
Male
/
Streptomycin
/
Follow-Up Studies
/
Treatment Outcome
/
Adult
Type of study:
Controlled clinical trial
/
Observational study
/
Prognostic study
Language:
English
Journal:
Indian J Med Sci
Year:
2002
Type:
Article
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