Prevalence of hepatitis C virus (HCV) infection in Mumbai.
Indian J Med Sci
;
1997 Oct; 51(10): 378-85
Article
in English
| IMSEAR
| ID: sea-68378
ABSTRACT
A study was carried out to determine the prevalence of Hepatitis C virus (HCV) in Mumbai among certain high risk groups such as renal transplant recipients, multitransfused and haemodialysis patients; professional and voluntary blood donors and viral hepatitis cases for comparison. Repeated testing of 602 subjects for antibodies to HCV using a second generation ELISA assay (Abbott, USA) showed an overall prevalence of 16.9%. We found 36.4% of multitransfused patients, 27.8% of renal failure cases and 26.2% of renal transplant recipients to be seropositive. Voluntary blood donors in our series showed a surprisingly high prevalence of 15.9%, and this group needs further investigation. Fifty-six of these sera (of which 45 were anti-HCV positive) were tested for HCV RNA by PCR and 14(31.1%) of the seropositive samples were also HCV RNA positive. The present investigation not only shows a high prevalence of HCV in the study groups but also proves the presence of HCV genomes in a significant proportion.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pregnancy Complications, Infectious
/
Rural Population
/
Female
/
Humans
/
Male
/
Pregnancy
/
Serologic Tests
/
Blotting, Southern
/
Polymerase Chain Reaction
/
Prevalence
Type of study:
Diagnostic study
/
Etiology study
/
Prevalence study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Med Sci
Year:
1997
Type:
Article
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