Altered oxidant-antioxidant status in non-obese men with moderate essential hypertension.
Indian J Med Sci
;
2007 Jun; 61(6): 326-31
Article
in English
| IMSEAR
| ID: sea-68521
ABSTRACT
BACKGROUND:
Although a wide number of experimental evidences are available regarding oxidant-antioxidant disturbance in hypertension, clinical data supporting it is lacking in men in early stages of hypertension.AIMS:
The objective of the study was to evaluate oxidative status and antioxidant activities in males with stage I essential hypertension. MATERIALS ANDMETHODS:
Thirty hypertensives and 21 normotensives were included in the study. Protein carbonyl, reduced glutathione, glutathione peroxidase, catalase and fasting glucose were assessed in both the groups. STATISTICALANALYSIS:
Results were analyzed by student's 't' test and linear regression analysis test.RESULTS:
Plasma protein carbonyl and glutathione peroxidase were significantly increased and catalase and GSH were significantly reduced in the hypertensive group compared to normotensive subjects. There was a significant negative correlation between glutathione peroxidase and catalase in the test group.CONCLUSIONS:
The data from the present study indicates an alteration in oxidant-antioxidant status in non-obese men in early stages of essential hypertension.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Severity of Illness Index
/
Blood Glucose
/
Humans
/
Male
/
Catalase
/
Linear Models
/
Oxidative Stress
/
Adult
/
Protein Carbonylation
/
Glutathione
Language:
English
Journal:
Indian J Med Sci
Year:
2007
Type:
Article
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