Short-term results of initial trabeculectomy with intraoperative or postoperative 5-fluorouracil for primary glaucomas.
Indian J Ophthalmol
;
1997 Sep; 45(3): 173-6
Article
in English
| IMSEAR
| ID: sea-69910
ABSTRACT
Thirty-three eyes of 33 patients were prospectively evaluated to study the short term efficacy, safety, and overall surgical outcome of initial trabeculectomy for primary glaucomas with adjunctive intraoperative or postoperative 5-Fluorouracil (5-FU) use. Twelve eyes serving as controls underwent trabeculectomy without adjunctive antimetabolites. Eleven eyes received intraoperative 5-FU, while 10 eyes received subconjunctival 5-FU postoperatively. Intraocular pressure (IOP) was maintained below 22 mmHg at 3 months of follow up in 90.9% and 80% of patients in the intraoperative and postoperative 5-FU groups, respectively, without use of additional antiglaucoma medications, whereas 66.7% of the patients in the control group achieved similar IOP levels. Hypotony (IOP < 6 mmHg) was seen more commonly after intraoperative 5-FU (27.3%). Corneal epithelial defects were seen exclusively in the postoperative 5-FU group (40%). The use of intraoperative 5-FU exclusively as a mode of antimetabolites delivery seems an acceptable alternative to enhance success rates of trabeculectomy for the primary glaucomas.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Ophthalmic Solutions
/
Postoperative Period
/
Safety
/
Female
/
Humans
/
Male
/
Trabeculectomy
/
Glaucoma, Angle-Closure
/
Glaucoma, Open-Angle
/
Retrospective Studies
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
Indian J Ophthalmol
Year:
1997
Type:
Article
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