Raised platelet thiobarbituric acid-reacting substances in proliferative Eales' disease.
Indian J Ophthalmol
;
2000 Dec; 48(4): 307-9
Article
in English
| IMSEAR
| ID: sea-70505
ABSTRACT
BACKGROUND:
Platelets are an elective site for oxidative stress owing to their high content of polyunsaturated fatty acid. Increased lipid peroxidation and elevated platelet thiobarbituric acid-reacting substances (TBARS) signal oxidative stress. This possibly leads to retinal neovascularization in Eales' disease.METHODS:
TBARS levels were estimated in consecutive cases of Eales' disease with neovascularisation (n = 26), Eales' disease without neovascularisation (n = 17) and healthy controls (n = 17).RESULTS:
Platelet TBARS levels in the cases of Eales' disease with neovascularisation, Eales' disease without neovascularisation, and healthy controls were 0.66 +/- 0.1, 0.57 +/- 0.11 and 0.42 +/- 0.14 n moles TBARS formed/hour/10(8) platelets respectively. Student's t-test showed a significant increase in platelet TBARS levels in cases with neovascularisation as compared to cases without neovascularization (p < 0.05) and healthy controls (p < 0.01).CONCLUSION:
The increase in platelet TBARS levels in proliferative Eales' disease is consistent with an emerging view that lipid peroxides may be associated with retinal neovascularisation.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Retinal Diseases
/
Vasculitis
/
Blood Platelets
/
Humans
/
Biomarkers
/
Lipid Peroxidation
/
Retinal Neovascularization
/
Adolescent
/
Thiobarbituric Acid Reactive Substances
/
Disease Progression
Language:
English
Journal:
Indian J Ophthalmol
Year:
2000
Type:
Article
Similar
MEDLINE
...
LILACS
LIS