Role of concanavalin A lectin in recognition of pterygium remnant after surgical excision: preliminary results of a prospective study.
Indian J Ophthalmol
;
2007 Sep-Oct; 55(5): 349-53
Article
in English
| IMSEAR
| ID: sea-70868
ABSTRACT
BACKGROUND:
Pterygium is one of the most common conjunctival diseases among ophthalmic pathologies. The frequency of recurrences is high, either after surgical treatment or after treatment combined with mitomycin C or beta-radiation therapy.AIMS:
The purpose of this study was to determine whether concanavalin A (ConA) lectin bound to the pterygial surface can be used to detect recurrence or remnants of pterygium after surgical excision. MATERIALS ANDMETHODS:
This was a prospective study on 20 patients with pterygium, divided in five stages, pre-surgery, early post-surgery (24h), late post-surgery (seven days), very late post-surgery (four weeks) and two months after the procedure. A drop of fluorescein-marked Con A (35 microg/mL) was instilled in the lower conjunctival eyelid sac and the eye was exposed to the light of a Wood's lamp for an average of five seconds.RESULTS:
Out of the 20 patients, eight patients were found to have fluorescent stretch marks over the scar corresponding to residual pterygial tissue at four weeks; two months after the procedure of re-surgery we observed no fluorescent remnants. All residual pterygia were confirmed through histochemistry studies.CONCLUSION:
It was possible to detect remnants of pterygium in postoperative patients and recurrences in early pre-clinical stages through the visualization of fluorescent ConA bound to the pterygial surface.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Postoperative Care
/
Rats
/
Recurrence
/
Humans
/
Pterygium
/
Photomicrography
/
Prospective Studies
/
Reproducibility of Results
/
Follow-Up Studies
/
Adolescent
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Language:
English
Journal:
Indian J Ophthalmol
Year:
2007
Type:
Article
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