Efficacy of topical and systemic itraconazole as a broad-spectrum antifungal agent in mycotic corneal ulcer. A preliminary study.
Indian J Ophthalmol
;
2001 Sep; 49(3): 173-6
Article
in English
| IMSEAR
| ID: sea-70989
ABSTRACT
PURPOSE:
To evaluate the efficacy of topical (1%) and systemic itraconazole against common fungi such as Aspergillus and other filamentous fungi that cause mycotic corneal ulcer.METHODS:
A prospective randomised, controlled study was done in 54 clinically suspected cases of fungal keratitis of which 44 were culture proven. Half the cases (n=27) with superficial involvement were treated with only topical itraconazole (1%) and the other half were treated with both topical and systemic itraconazole.RESULTS:
Aspergillus, Penicillium and Fusarium were the most common fungi isolated. The ulcer resolved in 42 eyes (77%) and 12 eyes (23%) did not respond well to treatment. Four of 12 non-responding eyes were caused by Fusarium species.CONCLUSION:
Itraconazole, given either topically or systemically, is effective in treating mycotic corneal ulcers.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Penicillium
/
Aspergillus
/
Female
/
Humans
/
Male
/
Eye Infections, Fungal
/
Corneal Ulcer
/
Administration, Oral
/
Prospective Studies
/
Administration, Topical
Type of study:
Controlled clinical trial
/
Observational study
Language:
English
Journal:
Indian J Ophthalmol
Year:
2001
Type:
Article
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