Effect of combination antiretroviral therapy on cytomegalovirus retinitis.
Indian J Ophthalmol
;
2002 Mar; 50(1): 29-33
Article
in English
| IMSEAR
| ID: sea-71213
ABSTRACT
PURPOSE:
To study the various changes in the course of cytomegalovirus (CMV) retinitis following combination antiretroviral treatment.METHODS:
Combination antiretroviral treatment was given to 12 patients with active CMV retinitis following which all anti-CMV medications were discontinued once the CD4 cell counts were > 100/mm3 for 3 months.RESULTS:
The median CD4 cell count increased from 36.5/mm3 (range, 3-74/mm3) at baseline to 175.5/mm3 (range, 97-410/mm3) at 3 months. No patient had reactivation of CMV retinitis or developed extraocular CMV infection during median follow-up of 16.7 months. In one patient with peripheral active CMV retinitis, the retinitis resolved completely and remained so throughout the follow-up period without specific anti-CMV treatment. Five (41.7%) patients had immune recovery vitritis.CONCLUSION:
Patients receiving combination antiretroviral treatment following treatment for CMV retinitis have better control of CMV retinitis but immune recovery vitritis is a common sequelae. Reactivation of CMV retinitis is common in patients who discontinue combination antiretroviral treatment.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Antiviral Agents
/
Female
/
Humans
/
Male
/
CD4-Positive T-Lymphocytes
/
Visual Acuity
/
Prospective Studies
/
Follow-Up Studies
/
Treatment Outcome
/
AIDS-Related Opportunistic Infections
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Language:
English
Journal:
Indian J Ophthalmol
Year:
2002
Type:
Article
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