Role of prophylactic intravitreal antibiotics in open globe injuries.
Indian J Ophthalmol
;
2003 Mar; 51(1): 39-44
Article
in English
| IMSEAR
| ID: sea-71221
ABSTRACT
PURPOSE:
To determine the efficacy of prophylactic intravitreal antibiotics in reducing the incidence of endophthalmitis after trauma.METHODS:
This was a prospective, randomised, case control study of 70 consecutive patients with open globe injury. The patients were prospectively randomised into group I (32 eyes) and group II (38 eyes). Group I patients were given prophylactic intravitreal injection of vancomycin 1 mg and ceftazidime 2.25 mg at the conclusion of primary repair. Group II patients were not given prophylactic intravitreal antibiotics. All the patients received intravenous ciprofloxacin.RESULTS:
The incidence of endophthalmitis was higher in group II (7 of 38 eyes; 18.42%) compared to group I (2 of 32 eyes; 6.25%). Both the patients who developed endophthalmitis despite prophylactic intravitreal antibiotics in group I had an initially undetected intraocular foreign body (eyelash) in the vitreous cavity.CONCLUSIONS:
Prophylactic intravitreal broad spectrum antibiotic injection decreases the risk of post-traumatic endophthalmitis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Vitrectomy
/
Vitreous Body
/
Female
/
Humans
/
Male
/
Vancomycin
/
Eye Injuries, Penetrating
/
Ceftazidime
/
Child
/
Child, Preschool
Type of study:
Controlled clinical trial
/
Observational study
/
Risk factors
Language:
English
Journal:
Indian J Ophthalmol
Year:
2003
Type:
Article
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