Serological responses to hepatitis B virus infection in multi-transfused thalassemic children.
Indian Pediatr
;
1992 Jan; 29(1): 73-7
Article
in English
| IMSEAR
| ID: sea-7150
ABSTRACT
One hundred children with beta-thalassemia major were studied prospectively. A one time analysis of serum samples was carried out for a battery of hepatitis B viral markers viz., HBsAg, anti-HBs and anti-HBc. Seven mutually different serological patterns were observed. The commonest profile seen in 49 patients was a combined seropositivity for anti-HBc and anti-HBs indicating past HBV infection with persisting immunity. Definite evidence of active HBV infection (seropositivity for HBsAg and/or HBeAg) was demonstrated in 10 cases, six of these were HBsAg positive. Anti-HBc positivity alone was detected in 17 patients. The remaining 24 children were seropositive for anti-HBs alone suggesting a possible passive transmission of anti-HBs through blood transfusion.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Thalassemia
/
Blood Transfusion
/
Humans
/
Child
/
Child, Preschool
/
Developing Countries
/
Hepatitis B
/
Hepatitis B Antibodies
/
Hepatitis B Surface Antigens
/
India
Country/Region as subject:
Asia
Language:
English
Journal:
Indian Pediatr
Year:
1992
Type:
Article
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