Clinico-biochemical study of experimental complicated cataracts.
Indian J Ophthalmol
;
1991 Oct-Dec; 39(4): 148-50
Article
in English
| IMSEAR
| ID: sea-71885
ABSTRACT
Clinically observed complicated cataracts, generally do not have a definite causal factor. We studied the effects of E. coli toxin injected suprachoroidally, to simulate the effect of toxins released by extraocular organisms on the lens. 79.2% of eyes had a definable cataract at the end of the 6th week of observation. The biochemical changes portrayed an increased oxidative activity in the lens, evidenced by a fall in glutathione concentration, and the consequent tertiary reorientation of proteins to increase insoluble proteins, forming a cataract.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Ascorbic Acid
/
Rabbits
/
Cataract
/
Lipopolysaccharides
/
Crystallins
/
Disease Models, Animal
/
Endotoxins
/
Escherichia coli
/
Lens, Crystalline
/
Animals
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Ophthalmol
Year:
1991
Type:
Article
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