Renal amyloidosis--a clinicopathologic study.
Indian J Pathol Microbiol
;
1996 Jul; 39(3): 179-85
Article
in English
| IMSEAR
| ID: sea-73912
ABSTRACT
A total of 19,075 necropsies and 1169 renal biopsies were scrutinised over a period of 20 years (1973-1992) retrospectively with an aim to study the incidence and pattern of renal amyloidosis in Nair Hospital. A total of 75 cases with amyloidosis were detected, 33 from the necropsy series (0.162%) and 42 from biopsies (3.59%). Secondary amyloidosis was seen in 82.66% and primary amyloidosis in 10.66%. Tuberculosis of various organs was the main cause of secondary amyloidosis (79.03%). Nephrotic syndrome was the common mode of presentation (52%). Besides kidney, which were involved in all cases, the liver, spleen and adrenals were other commonly involved organs at necropsy. Renal failure was the leading cause of death (51.51%). Thioflavine-T proved to be more sensitive technique than other conventional staining methods. The potassium permanganate test is a useful test to distinguish secondary amyloid fibrils from other amyloid fibrils. Abdominal fat aspiration may prove to be specific, sensitive and a routine procedure enabling the early diagnosis of amyloidosis leading to increased incidence of amyloidosis during life than at necropsy.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Tuberculosis
/
Female
/
Humans
/
Male
/
Adult
/
Renal Insufficiency
/
Amyloidosis
/
Kidney Diseases
/
Nephrotic Syndrome
Type of study:
Screening study
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
1996
Type:
Article
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