Immunophenotypic patterns in precursor T-cell neoplasm.
Indian J Pathol Microbiol
;
2007 Jan; 50(1): 75-7
Article
in English
| IMSEAR
| ID: sea-74000
ABSTRACT
T-cell lymphoproliferative disorders are a heterogeneous group of lymphoid neoplasm that can mimic both benign conditions and non-hematopoietic tumors. In routine clinical practice, morphology and immunophenotyping forms the basis of their diagnosis. In this retrospective analysis, we evaluate the utility of flow cytometric immunophenotyping patterns in diagnosis of precursor T-cell neoplasm. Aberrant expression of T-cell antigens was found in all the cases of precursor T-cell neoplasm. The residual normal T-lymphocytes, identifiable in majority of cases, were found to be useful in evaluation of quantitative differences in antigen expression by leukemic cells. A careful analysis of flow cytometric immunophenotyping data can provide additional information which is useful for diagnosis of precursor T-cell neoplasm. This information can be further utilized for analysis of minimal residual disease in these tumors.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Humans
/
Male
/
T-Lymphocytes
/
Leukemia, T-Cell
/
Antigens, CD
/
Child
/
Retrospective Studies
/
Immunophenotyping
/
Adolescent
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS