Nerve cell markers in ossifying fibromyxoid tumour of soft parts.
Indian J Pathol Microbiol
;
2001 Apr; 44(2): 163-7
Article
in English
| IMSEAR
| ID: sea-74265
ABSTRACT
Reported herein are two benign ossifying fibromyxoid tumors (OFMTs) of the soft tissues in axilla and terminal phalanx respectively. Both cases on immunohistochemistry (IHC) showed reactivity for vimentin, S-100 protein and glial fibrillary acidic protein (GFAP) antibodies. In addition, a focal/diffuse strong positivity for neurofilament (NF) and neuron specific enolase (NSE) was observed. Electron microscopy in one instance revealed abundant intermediate filaments, primitive cell junctions and a focally present external lamina. In the light of nerve cell differentiation of these tumors and the similarity of IHC profile and EM features of OFMT to a poorly differentiated malignant peripheral nerve sheath tumor (MPNST); it is suggested that OFMT is a variably differentiated PNST rather than a simple Schwannian neoplasm as is believed.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Phosphopyruvate Hydratase
/
Soft Tissue Neoplasms
/
Vimentin
/
Humans
/
Male
/
S100 Proteins
/
Biomarkers, Tumor
/
Ossification, Heterotopic
/
Nerve Sheath Neoplasms
/
Adult
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
2001
Type:
Article
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