A comparative and evaluative study of cytological and histological grading system profile in malignant neoplasm of breast--an important prognostic factor.

ABSTRACT

Breast carcinoma is one of the leading causes of malignancy in females. Diagnosis of breast carcinoma is often made by fine needle aspiration biopsy. Nuclear grading is the most important prognostic factor. It is important to grade the breast carcinoma which will provide valuable information to the treating oncologist to plan the management. The purpose of the study is to compare the cytological grading with histological grading and to assess the prognosis according to the grade. 100 cases of breast carcinoma were graded cytologically by Robinson Grading system and 71 cases were graded histologically by modified Bloom-Richardson system and results of both were compared and statistical correlation was done. In the present study sensitivity and specificity of cytological grading system were 90.77% and 84.42% respectively.