Proliferating cell nuclear antigen immunostaining in breast carcinoma and its relationship to clinical and pathological variables.
Indian J Pathol Microbiol
;
1997 Jan; 40(1): 11-6
Article
in English
| IMSEAR
| ID: sea-74468
ABSTRACT
Tumour proliferative activity of 74 breast lesions was assessed by determining mitotic index and immunostaining for proliferative cell nuclear antigen using Peroxidase antiperoxidase method. The indices were correlated with histomorphology and clinical stage of the disease. Positively stained nuclei and mitotic figures were counted per 1000 cells to calculate Proliferating Cell Nuclear Antigen (PCNA) and mitotic index respectively. Sixty four cases stained positive for PCNA. The index ranged between 0 to 98. PCNA index was significantly low in benign lesions as compared to malignant lesions (p < 0.0002). There was a linear correlation between the mitotic index and PCNA index. PCNA index also showed significant correlation with tumour size and histologic grade; however, it had no correlation with axillary lymph node status.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Breast Neoplasms
/
Female
/
Humans
/
Immunohistochemistry
/
Carcinoma
/
Proliferating Cell Nuclear Antigen
/
Lymphatic Metastasis
/
Mitotic Index
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
1997
Type:
Article
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