Role of AgNORs in diagnosis of early malignant lesions of gall bladder.
Indian J Pathol Microbiol
;
1995 Oct; 38(4): 383-8
Article
in English
| IMSEAR
| ID: sea-74725
ABSTRACT
Sections from eighty nine specimens of gall bladder including 40 cases of chronic cholecystitis, 9 dysplasia 15 well differentiated adenocarcinoma, 14 moderately differentiated adenocarcinoma and 11 poorly differentiated adenocarcinomas were studied for argyrophilic nucleolar organizer regions (AgNOR's). The difference between mean +/- SD NOR counts of chronic cholecystitis (1.97 +/- 0.28), dysplasia (5.6 +/- 0.88) well differentiated adenocarcinoma (7.2 +/- 0.30) and moderately differentiated adenocarcinoma (8.0 +/- 0.63) was statistically significant (p < 0.001). NOR counts of poorly differentiated adenocarcinoma (8.5 +/- 0.78) were higher than moderately differentiated carcinoma but the difference was not statistically significant. Despite the significant difference in the mean values, a considerable overlap in the NOR counts of individual cases of different groups was observed suggesting that though NOR counts can not act as a specific diagnostic parameter for diagnosis of early carcinoma and dysplasia in isolated cases, they may prove to be a good adjunct to already existing parameters like imaging techniques or cytology.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Silver
/
Staining and Labeling
/
Humans
/
Adenocarcinoma
/
Cell Differentiation
/
Cholecystitis
/
Gallbladder
/
Gallbladder Neoplasms
/
Nucleolus Organizer Region
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
1995
Type:
Article
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