Histological and functional correlation of thyroid carcinoma by immunohistochemistry.
Indian J Pathol Microbiol
;
1990 Jan; 33(1): 35-40
Article
in English
| IMSEAR
| ID: sea-74972
ABSTRACT
40 cases of thyroid carcinoma comprising of 22 follicular, 11 papillary, 4 medullary, 2 anaplastic and 1 medullary carcinoma with focal areas of papillary differentiation were selected for this immunohistochemical study for the presence of thyroglobulin, calcitonin and somatostatin. As per the functional classification recommended by Otto L Jungberg, 22 cases were well differentiated, 13 were of intermediate differentiation with 3 poorly differentiated cases. 2 cases of anaplastic carcinoma were negative for all the 3 markers. Correlation between functional classification and histological pattern show 77% of the well differentiated type to be of follicular pattern with the rest consisting of papillary carcinoma. In the intermediate type 38.4% were follicular carcinoma, 15.3% medullary carcinoma and the rest, papillary carcinoma. Poorly differentiated type consisted of 2 medullary carcinomas. Contrary to previous reports, functional differentiation did not always correlate with histological pattern.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Thyroid Neoplasms
/
Immunohistochemistry
/
Carcinoma
/
Carcinoma, Papillary
/
Adenocarcinoma
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
1990
Type:
Article
Similar
MEDLINE
...
LILACS
LIS