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Detection of HPV16 and 18 by in situ hybridization in precancerous and cancerous lesions of cervix.
Indian J Pathol Microbiol ; 2006 Jul; 49(3): 345-7
Article in English | IMSEAR | ID: sea-75658
ABSTRACT
Fifty cervical biopsies from women with preinvasive and invasive malignancies of uterine cervix and ten normal cervical biopsies were examined for the presence of human papilloma virus (HPV) 16 and 18 DNA sequences by in situ hybridization (ISH) method with biotinylated DNA probes. The overall positivity of HPV DNA was 48% (24/50). The positivity of HPV 16 DNA for low grade squamous intraepithelial lesion (LSIL), high grade squamous intraepithelial lesions (HSIL) and squamous cell carcinoma (SCC) were 33.33%, 45.45%, 42.30% respectively. The positivity for HPV 18 DNA for LSIL, HSIL and SCC were 0%, 18.18%, 30.76% respectively. Two cases of cervical adenocarcinomas showed positivity for HPV 18 DNA only.
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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Biopsy / Female / Humans / DNA, Viral / Carcinoma, Squamous Cell / DNA Probes / Uterine Cervical Neoplasms / Cervix Uteri / In Situ Hybridization / Biotinylation Type of study: Diagnostic study Language: English Journal: Indian J Pathol Microbiol Year: 2006 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Biopsy / Female / Humans / DNA, Viral / Carcinoma, Squamous Cell / DNA Probes / Uterine Cervical Neoplasms / Cervix Uteri / In Situ Hybridization / Biotinylation Type of study: Diagnostic study Language: English Journal: Indian J Pathol Microbiol Year: 2006 Type: Article