An evaluation of ductal carcinoma in-situ of breast and its correlation with the grade of associated invasive component.

ABSTRACT

Twenty-five cases of Ductal carcinoma in situ(DCIS), of breast with an associated invasive component were selected for this study. The aim was to identify the percentage of malignant cases having DCIS component, to analyse the distribution of DCIS according to architecture and cytonuclear grading and evaluate the correlation between grade of DCIS with that of associated invasive component. The DCIS component was classified according to traditional architectural classification and Van-Nuys cytonuclear classification. The grading of the invasive component was done according to Nottingham's modification of Bloom-Richardson system. Architecturally 72% of DCIS components were of pure form, 28% were of mixed pattern. According to cytonuclear grading 24% cases had grade-I, 28% grade-II and 48% grade-III DCIS. The invasive component showed 16% cases in grade-III. After correlating the grade of DCIS and invasive component 91% positive correlation was found in grade-III cases followed by 66.6% in grade-I and 57.1% in grade-II cases.