Detection of anti-PPD IgG antibody and PPD-induced delayed type hypersensitivity in anterior uveitis patients.
Indian J Pathol Microbiol
;
1997 Jul; 40(3): 303-7
Article
in English
| IMSEAR
| ID: sea-75772
ABSTRACT
Present study relates to the results of anti-PPD IgG, anti-A60 and antinuclear antibodies and PPD-induced delayed type hypersensitivity (DTH) in 17 anterior uveitis, (AU) patients. Results of anti-PPD IgG assay revealed detection of higher mean antibody level (O.D. 0.11 +/- 0.06) compared to healthy controls (O.D. 0.04 +/- 0.03), other eye disease controls (O.D. 0.05 +/- 0.003) and leprosy controls (O.D. 0.03 +/- 0.03). Anti-A60 IgM antibody assay revealed insignificant differences in mean antibody levels between various groups. Four of 17(23.5%) AU patients and 1(5.8%) subject each, belonging to other eye disease and healthy control groups had raised anti-nuclear antibody index. Findings of PPD skin test revealed detection of moderate to strong (2 to 4+) reactivity in 14 (82%). AU patients. Conversely, 13(76%) healthy controls and 8(47%) other eye disease controls gave mild (1+) reactivity. Results of this study suggested possible role of hypersensitivity to mycobacterial antigens in pathogenesis of anterior uveitis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Tuberculin
/
Humans
/
Immunoglobulin G
/
Case-Control Studies
/
Uveitis, Anterior
/
Antibodies, Antinuclear
/
Hypersensitivity, Delayed
/
Antibodies, Bacterial
/
Mycobacterium tuberculosis
Type of study:
Diagnostic study
/
Observational study
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
1997
Type:
Article
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