AML1-ETO positive AML: first report from India.
Indian J Pathol Microbiol
;
2007 Jul; 50(3): 652-4
Article
in English
| IMSEAR
| ID: sea-75916
ABSTRACT
Translocation (8;21) is associated with few typical morphological features and favorable prognosis. All patients of AML and MDS with increased blasts (N = 35) according to FAB criteria, presenting (between Jan 2004 to June 2005) to the Department of Hematology, AIIMS were studied. RT-PCR was done for the AML1-ETO fusion transcript in all cases. Overall incidence of AML1-ETO was 28.57% and no correlation was found between AML1-ETO positivity and clinical or hematological parameters except for a direct correlation with absolute blast count (ABC) (a lower ABC in the AML1-ETO positive cases). Interestingly, 1/3 MDS cases were positive for the same fusion transcript and thus, it appears worthwhile to look for AML1-ETO in all cases of MDS with increased blasts. Objective morphological evaluation using a scoring system based on morphological features was not helpful in predicting positivity for AML1-ETO. The effect of this translocation on long-term survival could not be determined by the present study.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Translocation, Genetic
/
Myelodysplastic Syndromes
/
Chromosomes, Human, Pair 8
/
Chromosomes, Human, Pair 21
/
Aged
/
Female
/
Humans
/
Male
/
Leukemia, Myeloid, Acute
/
Oncogene Proteins, Fusion
Type of study:
Incidence study
/
Prognostic study
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
2007
Type:
Article
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