Renal function and cardiac angiography.
Indian J Pediatr
;
2006 Jan; 73(1): 49-53
Article
in English
| IMSEAR
| ID: sea-78329
ABSTRACT
OBJECTIVE:
To study the effect of non-ionic contrast medium on renal function in children with cardiovascular disease.METHODS:
Analysis of renal function in 98 children with cardiovascular disease before and after the use of Iopamidol, Iohexol, and Ioversol was done for angiography. Serum creatinine (s-Cre), urinary N-acetyl-beta-D-glucosaminase (u-NAG), urinary beta 2-microglobulin (u-BMG), and urinary alpha 1-microglobulin (u-AMG) levels were evaluated.RESULTS:
Although s-Cre levels remained unchanged, u-NAG/Cre, u-AMG/Cre and u-BMG/Cre significantly increased 12 hours after angiography. Levels of u-NAG/Cre, u-BMG/Cre, and u-AMG/Cre after angiography were significantly higher in neonates and infants (age< 12-months, n=32) than in children (age>1-year, n=61), in patients with more than 5 ml/kg of contrast medium (n=25) than in those with less than 5 ml/kg (n=70) and in cyanotic patients (n=13) than in non-cyanotic (n=80) patients.CONCLUSION:
Transient renal tubular dysfunction occurred in all of these three non-ionic contrast mediums. Although renal tubular function was intact on a long-term basis, one should be careful of contrast medium-induced nephropathy, especially in neonates and infants, in patients receiving more than 5 ml/kg of contrast mediums in total, and in patients with cyanotic heart disease in using non-ionic contrast mediums.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Triiodobenzoic Acids
/
Urine
/
Iohexol
/
Iopamidol
/
Humans
/
Infant, Newborn
/
Cardiac Catheterization
/
Child
/
Child, Preschool
/
Adolescent
Language:
English
Journal:
Indian J Pediatr
Year:
2006
Type:
Article
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