Lupus nephritis in children.
Indian J Pediatr
;
1999 Mar-Apr; 66(2): 215-23
Article
in English
| IMSEAR
| ID: sea-78859
ABSTRACT
Systemic lupus erythematosus (SLE) is an autoimmune disease with varied clinical manifestations. Children and adolescents comprise one-fourth of affected patients with SLE and 40-80% of them have renal involvement. Lupus nephritis (LN) may present with mild urinary abnormalities or fulminant acute nephritis and renal failure. Diffuse proliferative glomerulonephritis (WHO class IV) is the predominant histological presentation in children and more common in boys than girls. This probably is one of the main reasons for the high mortality reported in the initial studies. Early diagnosis and aggressive treatment have led to improvement prognosis in these children. Cytotoxic therapy including intravenous cyclophosphamide has a definite role in the management WHO class IV and occasionally class III lupus nephritis. Prolonged steroid and cytotoxic therapy may lead to significant toxicity.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Prognosis
/
Azathioprine
/
Biopsy
/
Lupus Nephritis
/
Female
/
Humans
/
Male
/
Child
/
Cyclophosphamide
/
Glucocorticoids
Type of study:
Prognostic study
/
Screening study
Language:
English
Journal:
Indian J Pediatr
Year:
1999
Type:
Article
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