Prognostic factors relating to outcome of severe malaria among children in Bangladesh.
Bangladesh Med Res Counc Bull
;
2001 Apr; 27(1): 1-8
Article
in English
| IMSEAR
| ID: sea-79
ABSTRACT
This study was done in the Paediatric in-patient department of Chittagong Medical College Hospital (CMCH), Chittagong, Bangladesh to identify and quantify the prognostic factors associated with increased mortality in severe malaria (SM) cases. All the patients with parasitologically confirmed clinical syndromes of SM, admitted between June 1997 and May 1998, were included. A total of 53 consecutive cases were studied. Cerebral malaria (CM) was the commonest type of SM, observed in 36(68%) cases, second commonest type was severe anaemia 13(25%). More than one type of severe manifestations were present in 23(44%) cases. Overall case fatality rate (CFR) was 17% and it was 30% among those who had multi-organ manifestations. Important poor prognostic clinical variables were Blantrye coma score (BCS) score of 0 and 1 on day 1 (OR = 7.78) and day 2(OR = 40.0), multi-organ manifestations (OR = 6.8) and in-hospital complications (OR = 5.18). Important poor prognostic laboratory variables were day 2 parasite count > 50,000/cmm (OR = 5.5), blood glucose < 2.2 mmol/l (OR = 21.5) and raised CSF protein > 50 mg/dl (OR = 7.0). It can be concluded that certain clinical variables e.g. low BCS on day 1 & 2, multi-organ manifestations, in-hospital complications; and laboratory variables e.g. high parasite count, low blood glucose level, raised CSF protein levels are associated with increased mortality rate in SM cases.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Prognosis
/
Bangladesh
/
Severity of Illness Index
/
Blood Glucose
/
Female
/
Humans
/
Male
/
Infant, Newborn
/
Glasgow Coma Scale
/
Cerebrospinal Fluid
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Bangladesh Med Res Counc Bull
Year:
2001
Type:
Article
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