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Neonatal screening for glucose-6-phosphate dehydrogenase deficiency.
Indian J Pediatr ; 2005 Oct; 72(10): 835-7
Article in English | IMSEAR | ID: sea-79336
ABSTRACT

OBJECTIVE:

This study was carried out to detect the incidence of erythrocytic Glucose-6 -Phosphate dehydrogenase (G-6-PD) deficiency, to compare the incidence of hyperbilirubinemia in G-6-PD deficient neonates as compared to G-6-PD normal neonates and to asses the usefulness of neonatal screening for G-6-PD deficiency.

METHOD:

In a retrospective hospital based study 2,479 male and female neonates consecutively born at Indraprastha Apollo hospital between July 1998 to June 2003 who were screened for G-6-PD levels were evaluated for the incidence of G-6-PD deficiency.

RESULTS:

Incidence of G-6-PD deficiency was found to be 2.0%. Incidence in males was 283% and female was 1.05%. The incidence of hyperbilirubinemia was found to be 32% in G-6-PD deficient neonates which was significantly higher than the incidence of hyperbilirubinemia in neonates with normal G-6-PD, which was 12.3% (P< 0.001).

CONCLUSION:

Our data suggests that neonatal screening for G-6-PD deficiency is a useful test for preventing and early treatment of complications associated with it.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Phototherapy / Bilirubin / Female / Humans / Male / Infant, Newborn / Sex Factors / Retrospective Studies / Cohort Studies / Age Factors Type of study: Diagnostic study / Etiology study / Incidence study / Observational study / Risk factors / Screening study Country/Region as subject: Asia Language: English Journal: Indian J Pediatr Year: 2005 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Phototherapy / Bilirubin / Female / Humans / Male / Infant, Newborn / Sex Factors / Retrospective Studies / Cohort Studies / Age Factors Type of study: Diagnostic study / Etiology study / Incidence study / Observational study / Risk factors / Screening study Country/Region as subject: Asia Language: English Journal: Indian J Pediatr Year: 2005 Type: Article