Neonatal screening for glucose-6-phosphate dehydrogenase deficiency.
Indian J Pediatr
;
2005 Oct; 72(10): 835-7
Article
in English
| IMSEAR
| ID: sea-79336
ABSTRACT
OBJECTIVE:
This study was carried out to detect the incidence of erythrocytic Glucose-6 -Phosphate dehydrogenase (G-6-PD) deficiency, to compare the incidence of hyperbilirubinemia in G-6-PD deficient neonates as compared to G-6-PD normal neonates and to asses the usefulness of neonatal screening for G-6-PD deficiency.METHOD:
In a retrospective hospital based study 2,479 male and female neonates consecutively born at Indraprastha Apollo hospital between July 1998 to June 2003 who were screened for G-6-PD levels were evaluated for the incidence of G-6-PD deficiency.RESULTS:
Incidence of G-6-PD deficiency was found to be 2.0%. Incidence in males was 283% and female was 1.05%. The incidence of hyperbilirubinemia was found to be 32% in G-6-PD deficient neonates which was significantly higher than the incidence of hyperbilirubinemia in neonates with normal G-6-PD, which was 12.3% (P< 0.001).CONCLUSION:
Our data suggests that neonatal screening for G-6-PD deficiency is a useful test for preventing and early treatment of complications associated with it.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Phototherapy
/
Bilirubin
/
Female
/
Humans
/
Male
/
Infant, Newborn
/
Sex Factors
/
Retrospective Studies
/
Cohort Studies
/
Age Factors
Type of study:
Diagnostic study
/
Etiology study
/
Incidence study
/
Observational study
/
Risk factors
/
Screening study
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Pediatr
Year:
2005
Type:
Article
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