Efficacy of combined treatment with growth hormone and gonadotropin releasing hormone analogue in children with poor prognosis of adult height.
Indian Pediatr
;
2007 Jul; 44(7): 497-502
Article
in English
| IMSEAR
| ID: sea-7989
ABSTRACT
OBJECTIVE:
This study was conducted to study the role of combination therapy of growth hormone and Gonadotropin-releasing hormone (GnRH) analogues in girls with idiopathic central precocious puberty (CPP) or idiopathic short stature (ISS).METHODS:
Five girls with CPP (median age 9.1 y, pubertal stage 2-3) (3 of them previously treated with GnRH analogue (GnRHa) for 16.2 +/- 0.3 months) and 8 girls with ISS (median age 11.4 y, pubertal stage 2-3) (previously treated with GH for 10.95 +/- 1.42 months), were treated with recombinant human GH (0.33 mg/kg/week) and GnRHa (3.75 mg/28 days) for 22 months.RESULTS:
Height of girls with CPP improved from - 1.3 to - 0.2 SDS and height for BA from - 2.1 to - 0.6 SDS (P = 0.042). Predicted adult height (PAH) improved from - 3.1 to - 0.6 SDS (P = 0.042). In girls with ISS only PAH improved from - 3.0 to - 1.5 SDS (P = 0.025).CONCLUSION:
Combined treatment improves height and PAH in CPP. Height in ISS is also improved however not significantly.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Puberty, Precocious
/
Body Height
/
Bone Development
/
Algorithms
/
Female
/
Humans
/
Growth Hormone
/
Child
/
Gonadotropin-Releasing Hormone
/
Treatment Outcome
Type of study:
Prognostic study
Language:
English
Journal:
Indian Pediatr
Year:
2007
Type:
Article
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