Haemolytic disease of newborn.
Indian J Pediatr
;
2001 Feb; 68(2): 167-72
Article
in English
| IMSEAR
| ID: sea-80000
ABSTRACT
Hemolytic disease of the newborn (HDN) occurs due to maternal IgG antibodies crossing the placenta thereby producing hemolysis mainly due to Rh, ABO and Kell groups. A systematic approach to the Rh HDN involves an obstetric history of previous isoimmunized baby, timing and regular monitoring of maternal Rh antibodies and pigment assay of amniotic fluid. Timely decision regarding in utero transfusion and early termination of pregnancy based on the maternal monitoring has radically improved the outcome of these babies. Antenatal prophylaxis with anti D has resulted in great reduction in the magnitude of Rh problem. The fetal blood sampling and in-utero intravenous transfusions has made it possible for almost 100% survival of isoimmunized pregnancies without hydrops. Alternative methods--IVIG and plasma exchange are still of limited application. ABO HDN though common is not a serious form of disease and dose not warrants invasive antenatal monitoring. Anti-Kell is found in patients having received multiple transfusions and the rapid progress of hemolysis in them may not allow such systematic follow up as in Rh HDN.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Prenatal Diagnosis
/
Rh-Hr Blood-Group System
/
Blood Transfusion, Intrauterine
/
Algorithms
/
Female
/
Humans
/
Infant, Newborn
/
Pregnancy
/
Erythroblastosis, Fetal
/
Isoantibodies
Type of study:
Diagnostic study
/
Prognostic study
Language:
English
Journal:
Indian J Pediatr
Year:
2001
Type:
Article
Similar
MEDLINE
...
LILACS
LIS