Hematological responses to hydroxyurea therapy in multitransfused thalassemic children.
Indian J Pediatr
;
1997 May-Jun; 64(3): 395-8
Article
in English
| IMSEAR
| ID: sea-80018
ABSTRACT
Fifteen multi-transfused thalassemic children between 3-6 years of age (seven boys and eight girls) were administered hydroxyurea for 5 days and three such cycles were repeated at 15 days interval. Rise in hemoglobin levels was observed in 13, 8 and 7 cases, while rise in mean hemoglobin F was seen in 8, 11 and 10 cases following 1st, 2nd and 3rd course of hydroxyurea therapy respectively. Rise in hemoglobin level was associated with transient rise in fetal hemoglobin level. Though the changes in mean hemoglobin levels and hemoglobin F levels were statistically insignificant, a definite trend of rise in hemoglobin and hemoglobin F was observed.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Blood Transfusion
/
Female
/
Humans
/
Male
/
Fetal Hemoglobin
/
Drug Administration Schedule
/
Child
/
Child, Preschool
/
Follow-Up Studies
/
Treatment Outcome
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
Indian J Pediatr
Year:
1997
Type:
Article
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