Botulinum toxin in children with cerebral palsy.
Indian J Pediatr
;
2004 Dec; 71(12): 1087-91
Article
in English
| IMSEAR
| ID: sea-80352
ABSTRACT
Botulinum toxin is a neurotoxin that blocks the synaptic release of acetylcholine from cholinergic nerve terminals mainly at the neuromuscular junction, resulting in irreversible loss of motor end plates. It is being widely tried as a targeted antispasticity treatment in children with cerebral palsy. A number of studies have shown that it reduces spasticity and increases the range of motion and is particularly useful in cases with dynamic contractures. However improvement in function has not been convincingly demonstrated. It is an expensive mode of therapy and the injections need to be repeated after 3-6 months. Whereas Botulinum toxin can be a valuable adjunct in select cases, it should not be projected as a panacea for children with spastic cerebral palsy.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Botulinum Toxins
/
Humans
/
Cerebral Palsy
/
Child
/
Neuromuscular Agents
Language:
English
Journal:
Indian J Pediatr
Year:
2004
Type:
Article
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