Safety and efficacy of rifampicin in children with cholestatic pruritus.
Indian J Pediatr
;
2007 Mar; 74(3): 279-81
Article
in English
| IMSEAR
| ID: sea-80540
ABSTRACT
OBJECTIVE:
The present study aimed at verifying the safety and efficacy of rifampicin in ameliorating pruritus in cholestatic children.METHODS:
Twenty-three Egyptian children (14 boys and 9 girls), suffering from intractable pruritus of cholestasis, were included. Rifampicin was started at a dose of 10 mg/Kg/day in two divided doses and increased gradually to a maximum of 20 mg/Kg/day if there was no response. Liver function tests were followed up weekly.RESULTS:
Seventeen patients (74%) showed improvement of pruritus with rifampicin. None of the patients showed any deterioration in liver functions.CONCLUSION:
Rifampicin in a dose of 10-20 mg/Kg/day is safe and effective in ameliorating uncontrollable pruritus in children with persistent cholestasis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pruritus
/
Rifampin
/
Female
/
Humans
/
Male
/
Child
/
Child, Preschool
/
Cholestasis
/
Adolescent
/
Infant
Language:
English
Journal:
Indian J Pediatr
Year:
2007
Type:
Article
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