Prognostic value of direct bilirubin in neonatal hyperbilirubinemia.
Indian J Pediatr
;
2007 Sep; 74(9): 819-22
Article
in English
| IMSEAR
| ID: sea-80737
ABSTRACT
OBJECTIVE:
To determine the prognostic value of indirect and direct hyperbilirubinemia in neonates with jaundice.METHODS:
A cohort of 92 consecutive neonates reporting with hyperbilirubinemia to a tertiary care center were followed up till well and discharged, or, till death to assess risk and rate of mortality.RESULTS:
The baseline median values of total, direct and indirect bilirubin in the cohort of 21.8, 1.6 and 18.6 mg/dl, respectively, were used as cut-offs for high and low levels. Using survival analyses i.e. Kaplan-Meier plots, logrank tests and multivariate Cox proportional hazards regression models to adjust for other strong predictors such as receipt of breastfeeding, being small for gestational age (SGA) and exchange transfusion, high direct bilirubin (> or = median value of 1.6 mg/dl) was independently associated with a higher and faster mortality.CONCLUSION:
This study showed that direct bilirubin has independent and additive prognostic value and due attention should be given to newborns with raised levels.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Prognosis
/
Bilirubin
/
Female
/
Humans
/
Male
/
Infant, Newborn
/
Poisson Distribution
/
Proportional Hazards Models
/
Predictive Value of Tests
/
ROC Curve
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Pediatr
Year:
2007
Type:
Article
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