Comparison of two antibiotic regimens in the empirical treatment of severe childhood pneumonia.
Indian J Pediatr
;
2004 Nov; 71(11): 969-72
Article
in English
| IMSEAR
| ID: sea-80780
ABSTRACT
OBJECTIVE:
The diagnosis and the treatment of community-acquired severe pneumonia is still a serious child health problem in developing countries. The aim of this study is to evaluate the effectiveness of two different antibiotic regimens in the empirical treatment of severe childhood pneumonia.METHODOLOGY:
We enrolled 97 infants (aged 2-24 months) with severe community-acquired pneumonia in a randomized-controlled trial of 10 days of treatment with penicillin G+chloramphenicol (n46) or ceftriaxone (n51). We evaluated the effectiveness of treatments with symptoms and some laboratory tests during and at the end of the study.RESULTS:
The cure rates were similar in both groups and the antibiotic regimens in all patients were found effective (P< 0.001). The number of nurse rounds was much more in penicillin plus chloramphenicol group than ceftriaxone group.CONCLUSION:
Both penicillin G plus chloramphenicol and ceftriaxone are effective in the empirical treatment of severe community pneumonia of young children. In spite of more nurse visits for antibiotic treatment, penicillin G+ chloramphenicol combination may be a cheaper alternative to ceftriaxone in the treatment of childhood pneumonia.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Penicillin G
/
Turkey
/
Hospitals, Urban
/
Severity of Illness Index
/
Ceftriaxone
/
Female
/
Humans
/
Male
/
Drug Administration Schedule
/
Child, Hospitalized
Type of study:
Controlled clinical trial
/
Observational study
/
Prognostic study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Pediatr
Year:
2004
Type:
Article
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