Cytogenetics investigation in childhood chronic myeloid leukemia.
Indian J Pediatr
;
2000 Feb; 67(2): 107-12
Article
in English
| IMSEAR
| ID: sea-81255
ABSTRACT
Cytogenetics investigations, mostly from peripheral blood, were carried out in 30 children with CML. Amongst a sample of 30 patients, 18 had chronic myeloid leukemia of adult variety (ACML), while the remaining 12 children had the juvenile type of chronic myeloid leukemia (JCML). Sixteen (88.9%) out of the 18 patients suffering from ACML tested positive for the classical Philadelphia chromosome translocation t(9; 22). Of the remaining two ACML patients, one tested positive for t(9; 13; 22) while no visible chromosomal changes were observed in the other patient. The activity of Nucleolar Organizer Region (NOR) was significantly reduced in 11 (61.1%) of the 18 patients suffering from ACML, when compared to that of 21 normal healthy controls. Ten out of the 12 patients suffering from JCML had normal karyotypes, while monosomy 8 and 21 q deletion were seen in the remaining two patients respectively. Amongst the 30 CML patients, chromosomal abnormalities were observed in 19 patients. Variant Philadelphia chromosome translocation (9; 13; 22) and monosomy B were observed in ACML and JCML, respectively. In two ACML patients, cytogenetic studies were helpful in diagnosis of the disease.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Translocation, Genetic
/
Philadelphia Chromosome
/
Female
/
Humans
/
Male
/
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Child
/
Child, Preschool
/
Adolescent
/
Cytogenetic Analysis
Language:
English
Journal:
Indian J Pediatr
Year:
2000
Type:
Article
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