Role of antibody dependent cell mediated cytotoxicity in ABO hemolytic disease of the newborn.
Indian J Pediatr
;
1995 Sep-Oct; 62(5): 587-92
Article
in English
| IMSEAR
| ID: sea-81411
ABSTRACT
Study includes fifty O blood group mothers delivering A or B group infants suffering from jaundice and a control group consisting of thirty one O group mothers of non-jaundiced infants. Lytic ability of maternal IgG anti-A/anti-B was determined by 51Cr ADCC assay in which cord blood monocytes were used as effector cells. In control series mean% specific lysis (SL) was 18 +/- 3.1 for IgG anti-A and 17.9 +/- 3.1 for IgG anti-B. In jaundiced series IgG anti-A was more lytic than IgG anti-B. However, the increase in ADCC lysis was statistically insignificant. Even though > 132 titre was more often associated with > 35% SL, in general the immune A/B antibody titre showed poor correlation with ADCC lysis. Majority of the severe ABO-HDN cases had > 35% ADCC lysis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
ABO Blood-Group System
/
Female
/
Humans
/
Immunoglobulin G
/
Infant, Newborn
/
Pregnancy
/
Monocytes
/
Erythroblastosis, Fetal
/
Fetal Blood
/
Antibody-Dependent Cell Cytotoxicity
Language:
English
Journal:
Indian J Pediatr
Year:
1995
Type:
Article
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