Unusual lymphocytosis with systemic lupus erythematosus.
Indian J Pediatr
;
2008 Jul; 75(7): 748-50
Article
in English
| IMSEAR
| ID: sea-81750
ABSTRACT
A 15-year-old boy with systemic lupus erythematosus, who on a follow up visit complained of recurrent episodes of fever, easy fatiguability, and seizures. Investigations revealed lymphocytosis (95%), anemia, and a positive PCR for cytomegalovirus (CMV). Electron microscopy of the lymphocytes revealed intranuclear inclusion bodies supporting the diagnosis of CMV infection. The child was treated with ganciclovir and discharged. At discharge the child was afebrile. However, lymphocytosis persisted even after 9 months of discharge. Repeated screening for possible lymphoreticular malignancy was negative. It is likely that lymphocytosis in this child was due to persistence of CMV infection in host cells leading to continued provocation of the host immune system.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Antiviral Agents
/
Humans
/
Male
/
Lymphocytes
/
Ganciclovir
/
Adolescent
/
Cytomegalovirus Infections
/
Cytomegalovirus
/
Flow Cytometry
/
Anemia
Language:
English
Journal:
Indian J Pediatr
Year:
2008
Type:
Article
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