Plasma protein variations in hemophiliacs receiving factor replacement therapy.
Indian J Pediatr
;
2007 May; 74(5): 459-62
Article
in English
| IMSEAR
| ID: sea-81817
ABSTRACT
OBJECTIVE:
Post transfusion manifestations and its affiliated factors are vital to understand in a disease like hemophilia where multi-transfusions are given to the patients.METHODS:
To investigate the implications of factor replacement therapy on plasma proteins, 52 hemophiliacs and 68 carrier females were examined for 12 plasma proteins using various electrophoretic techniques.RESULTS:
Severe hemophiliacs showed raised levels ( p< 0.05) of a2 M, IgG and Albumins where values were found to be 4.78 +/- 0.865 g/l, 21.48 +/- 3.38 g/l, 66.26 +/- 11.92 g/l respectively at 95% confidence intervals however, controls and carriers showed trivial variations.CONCLUSION:
Juxtaposing the dissimilarities of 12 plasma proteins in carriers, controls and hemophiliacs, it has been gleaned that factor replacement therapy do play role when seen in severe hemophiliacs with raised levels.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Humans
/
Male
/
Factor VIII
/
Immunoglobulin G
/
Blood Proteins
/
Electrophoresis, Agar Gel
/
Hemophilia A
/
Anticoagulants
Language:
English
Journal:
Indian J Pediatr
Year:
2007
Type:
Article
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