Multidrug-resistant typhoid fever.
Indian J Pediatr
;
2007 Jan; 74(1): 39-42
Article
in English
| IMSEAR
| ID: sea-82027
ABSTRACT
OBJECTIVE:
To study the epidemiological pattern, clinical picture, the recent trends of multidrug-resistant typhoid fever (MDRTF), and therapeutic response of ofloxacin and ceftriaxone in MDRTF.METHODS:
The present prospective randomized controlled parallel study was conducted on 93 blood culture-proven Salmonella typhi children. All MDRTF cases were randomized to treatment with ofloxacin or ceftriaxone.RESULTS:
Of 93 children, 62 (66.6%) were MDRTF. 24 cases were below 5 years, 26 between 5-10 years and 12 were above 10 years. Male to female ratio was 1.85 1. Majority of cases came from lower middle socio-economic classes with poor personal hygiene. Fever was the main presenting symptom. Hepatomegaly and splenomegaly was present in 88% and 46% cases respectively. 19 (30.6%) cases developed complications. Mean defervescence time with ceftriaxone and ofloxacin was 4.258 and 4.968 days respectively.CONCLUSION:
MDRTF is still emerging as serious public and therapeutic challenge. Ceftriaxone is well-tolerated and effective drug but expensive whereas ofloxacin is safe, cost-effective and therapeutic alternative in treatment of MDRTF in children with comparable efficacy to ceftriaxone.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Prognosis
/
Salmonella typhi
/
Typhoid Fever
/
Blood
/
Severity of Illness Index
/
Infusions, Intravenous
/
Ceftriaxone
/
Female
/
Humans
/
Male
Type of study:
Controlled clinical trial
/
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Pediatr
Year:
2007
Type:
Article
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