Dexamethasone as an adjunctive treatment of bacterial meningitis.
Indian J Pediatr
;
1997 Jul-Aug; 64(4): 517-22
Article
in English
| IMSEAR
| ID: sea-84071
ABSTRACT
This study was conducted on 77 Libyan infants and children aged month to 10 years with acute bacterial meningitis. Upon admission, the patients were divided randomly in two groups. Group I (38 patients) received ceftriaxone plus dexamethasone i.v. Group II (39 patients) received ceftriaxone alone. Both groups were compared for mean changes in CSF sugar, CSF protein and CSF polymorph count at 4th day of treatment. There was a significant difference between the two groups in CSF sugar and protein changes (P < 0.05) but not in CSF polymorph (P > 0.05). Both groups showed prompt clinical response and similar occurrence of acute complications, fatality rate and permanent neurological sequelae. However, group I manifested shorter duration of fever (P < 0.05). Dexamethasone improved the inflammatory reaction in acute bacterial meningitis and shortened the duration of fever but it did not have any significant effect on the fatality and the occurrence of neurological sequelae of this disease.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Ceftriaxone
/
Female
/
Humans
/
Male
/
Dexamethasone
/
Cephalosporins
/
Child
/
Child, Preschool
/
Meningitis, Bacterial
/
Drug Therapy, Combination
Type of study:
Controlled clinical trial
Country/Region as subject:
Africa
Language:
English
Journal:
Indian J Pediatr
Year:
1997
Type:
Article
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