Microalbuminuria as a predictor of early glomerular injury in children with sickle cell disease.
Indian J Pediatr
;
2003 Apr; 70(4): 307-9
Article
in English
| IMSEAR
| ID: sea-84195
ABSTRACT
OBJECTIVE:
A cross sectional study was carried out to determine the prevalence of microalbuminuria in the pediatric patients with sickle cell disease.METHODS:
The study was carried out on 64 pediatric patients aged less than 14 years with documented HbSS, HbAS and HbS beta thalassemia, Microalbuminuria was estimated using single radial immuno diffusion technique. Majority of the study subjects were of HbSS type. 38.5% had symptoms for > 2 years. 18.8% of the study population had significant microalbuminuria (19.2% of SS type and 18.8% of Hb AS types).RESULT:
Microalbuminuria excretion was significantly more in patients > 9 years of age as compared to young patients (p < 0.05). Mean serum creatinine levels did not show any significant difference in the various study groups.CONCLUSION:
Microalbuminuria estimation is a very important clinical marker of preclinical glomerular damage in patients with sickle cell disease. It estimation would help in the early detection of such patients and prompt initiation of therapy.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Arterial Occlusive Diseases
/
Female
/
Humans
/
Male
/
Hemoglobins
/
Biomarkers
/
Comorbidity
/
Child
/
Child, Preschool
/
Prevalence
Type of study:
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
/
Screening study
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Pediatr
Year:
2003
Type:
Article
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