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Spontaneous hypoparathyroidism: clinical, biochemical and radiological features.
Indian J Pediatr ; 1989 Mar-Apr; 56(2): 267-72
Article in English | IMSEAR | ID: sea-84318
ABSTRACT
The clinical, biochemical and radiological features of spontaneously occurring hypoparathyroidism in 13 patients (mean age 9 years, range 4 months to 20 years) are highlighted. Nine patients presented with a history of generalised seizures and 2 were in acute hypocalcemic crisis at the time of admission. Ocular involvement (corneal opacities, cataract) was present in 3 patients and vitiligo in 1 patient. The serum calcium level was low (mean 5.46 mg/dl, range 5.0-7.2) and serum phosphorus level was high (mean 8.49 mg/dl, range 6-14 mg/dl) in all the patients. Six patients had elevated serum alkaline phosphatase (greater than 20 KAU). Radiological examination revealed osteopenia in 3 patients. Nine patients underwent a head CT scan; 5 had evidence of basal ganglia calcification. The findings of elevated serum alkaline phosphatase and osteopenia are at variance with existing literature and may possibly reflect pre-existing vitamin D deficiency.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Seizures / Basal Ganglia Diseases / Bone Diseases, Metabolic / Female / Humans / Male / Calcinosis / Child / Adolescent / Adult Country/Region as subject: Asia Language: English Journal: Indian J Pediatr Year: 1989 Type: Article
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Seizures / Basal Ganglia Diseases / Bone Diseases, Metabolic / Female / Humans / Male / Calcinosis / Child / Adolescent / Adult Country/Region as subject: Asia Language: English Journal: Indian J Pediatr Year: 1989 Type: Article