Double blind randomized comparative evaluation of nimesulide and paracetamol as antipyretics.
Indian Pediatr
;
1998 Jun; 35(6): 519-22
Article
in English
| IMSEAR
| ID: sea-8436
ABSTRACT
OBJECTIVE:
To compare the efficacy and safety of nimesulide and paracetamol as antipyretic agents.DESIGN:
Double blind, randomized clinical trial.METHODS:
Hospitalized patients having fever due to a variety of infections were given either drug in a randomized manner. (Nimesulide group = 49, Paracetamol group = 50). Serial axillary temperature was recorded after drug administration and side effects monitored.RESULTS:
The mean temperature after one hour of drug administration was significantly lower in nimesulide group (p < 0.05). Significantly fewer doses of nimesulide were required to bring down the temperature on the first day (p < 0.001). The mean maximum temperature recorded on second and third day was significantly lower in the nimesulide group (p < 0.05). Adverse reactions were seen in the form of epigastric pain and vomiting in one patient in Nimesulide group and three in paracetamol group.CONCLUSION:
Nimesulide is more effective than paracetamol as an antipyretic agent and is safe for use in infants and children.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Axilla
/
Sulfonamides
/
Vomiting
/
Body Temperature
/
Female
/
Humans
/
Male
/
Abdominal Pain
/
Child, Preschool
/
Anti-Inflammatory Agents, Non-Steroidal
Type of study:
Controlled clinical trial
/
Observational study
Language:
English
Journal:
Indian Pediatr
Year:
1998
Type:
Article
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