Immunological response to two hepatitis B vaccines administered in two different schedules.
Indian J Pediatr
;
2006 Jun; 73(6): 489-91
Article
in English
| IMSEAR
| ID: sea-84554
ABSTRACT
OBJECTIVES:
To evaluate the antibody response to a plasma derived hepatitis B vaccine containing pre-S and S antigens and a recombinant vaccine containing only S antigen and compare the two vaccines in 0, 1, 2 and 0, 1, 6, schedulesMETHODS:
One hundred fifty nine healthy infants were randomized to receive the vaccines in two different schedules. Anti HBs titers were estimated prior to the vaccination and then one-month following the second and third doses.RESULTS:
Both the vaccines produced a high rate of seroconversion and seroprotection. The antibody response was similar with both the vaccines and the 0, 1, 6, schedule induced a significantly higher antibody level than the 0, 1, 2, schedule.CONCLUSION:
0, 1, 6 schedule produces a higher antibody level than 0, 1, 2 schedule though both the schedules have good seroconversion and seroprotection rates with both the vaccines.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Humans
/
Male
/
Drug Administration Schedule
/
Serologic Tests
/
Viral Hepatitis Vaccines
/
Hepatitis B
/
Hepatitis B Antibodies
/
Hepatitis B Surface Antigens
/
Infant
Type of study:
Controlled clinical trial
/
Diagnostic study
Language:
English
Journal:
Indian J Pediatr
Year:
2006
Type:
Article
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